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Updated: Jan 7, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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CCL17-CCR4轴对突变的STAT6介导的微环境重塑和复发性/反射性扩散性大B细胞淋巴瘤的治疗阻力至关重要

Madelyn J Abraham1, Cynthia Guilbert2, Natascha Gagnon3

  • 1McGill University Montreal, Quebec Canada.

Cancer immunology research
|December 29, 2025
PubMed
概括

扩散型大B细胞淋巴瘤 (DLBCL) 中的STAT6突变通过通过CCR4吸引CD4+T细胞来驱动治疗耐药性. 抑制CCR4恢复了对多克索鲁比的敏感性,将其确定为复发性/耐药DLBCL的潜在治疗标.

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