在卡梅伦县西班牙裔队列中,认知障碍的心脏代谢指标
Fadi I Musfee1,2, Seema Agarwal2, Vahed Maroufy2,3
1Department of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX, USA.
糖尿病显著增加了西班牙裔/拉丁裔的认知障碍 (CI) 的风险,即使在年轻人中也是如此. 这凸显了管理糖尿病的重要性,以防止这一群体的认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 心脏病学 心脏病学
背景情况:
- 认知障碍 (CI) 和糖尿病和中风等危险因素在西班牙裔/拉丁裔 (H/L) 中很常见.
- 以前对H/L和CI的研究主要集中在老年人 (≥65岁).
研究的目的:
- 在较年轻的H/L队列中检查心脏代谢健康指标和CI之间的关联.
- 在卡梅伦县西班牙裔群体 (CCHC) 中使用前性研究设计.
主要方法:
- 分析了1240名CCHC参与者在基线和5年后的迷你心理状态检查 (MMSE) 数据.
- 认知障碍 (CI) 被定义为MMSE得分<24的认知障碍.
- 使用了根据年龄,教育,先前中风和APOE基因进行调整的混合后勤回归模型.
主要成果:
- 89.9%的参与者在65岁以下.
- 在调整后,糖尿病与CI (OR:2.11,95%CI:1.26-3.52) 的概率增加显著相关.
- 患有CI的人年龄较大,教育程度较低,患糖尿病的可能性更高,LDL水平较低,静脉压高.
结论:
- 糖尿病是CI的重要指标,跨越不同年龄,教育水平和APOE基因状态.
- 心脏代谢风险因素,特别是糖尿病,对CCHC队列的认知健康构成重大负担.
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