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PREHAAAB试验:等待开放腹腔大动脉瘤修复的患者多式预康复 - - 一项国际随机对照试验的研究方案
Miquel Coca-Martinez1,2, Robert J Doonan3, Chelsia Gillis4
1Department of Anesthesiology and Intensive Care, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
PloS one
|December 29, 2025
概括
多种模式的预康复可能会减少接受开放腹腔大动脉瘤 (AAA) 修复的患者的并发症. 这项研究调查了它在改善这一高风险手术群体的结果方面的有效性.
科学领域:
- 血管外科 血管外科
- 在外科手术期间的医学.
- 老年医学 老年医学
背景情况:
- 开放腹腔大动脉瘤 (AAA) 修复具有很高的术后并发症风险,特别是在功能能力较低的患者中.
- 关于预康复对开放AAA修复结果的影响的证据有限.
- 预康复包括在手术前对身体,营养和心理进行优化.
研究的目的:
- 评估多模式预康复计划在开放AAA修复后降低术后并发症的有效性.
- 评估预康复对住院,再入院,功能能力,生活质量和心理健康的影响.
主要方法:
- 一个多中心,国际随机对照试验,涉及152名参与者,计划接受选择性开放AAA手术.
- 参与者被随机分配到标准护理或为期6周的多模式预康复计划 (运动,营养,心理支持).
- 主要结局:术后并发症的发生率 (综合并发症指数). 二次结果:停留时间,再入院,功能能力,生活质量,焦虑和抑郁.
主要成果:
- 该部分应在研究完成并分析数据后填写.
结论:
- 这项试验解决了开放AAA手术术前手术优化的关键证据缺口.
- 预计这些发现将指导降低高风险患者患病率的最佳实践.
- 结果将有助于加强血管外科手术的恢复策略.
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