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低收入至中高收入国家关键人口的艾滋病毒自我检测和伙伴通知策略:混合方法系统审查

Lekey Khandu¹, Jonathan Hallett¹, Gemma Crawford¹

¹Faculty of Health Sciences, School of Population Health, Curtin University, Perth, Western Australia, Australia.

|December 29, 2025

概括

艾滋病毒自我检测 (HIVST) 是可以接受和可行的,用于识别艾滋病毒病例和通知合作伙伴,特别是在关键人群中. 辅助合作伙伴通知是减少感染的成本效益高的策略.

科学领域:

公共卫生公共卫生
流行病学流行病学
传染病控制和控制传染病

背景情况:

艾滋病毒自我检测 (HIVST) 对于诊断至关重要,但其整合到索引测试和合作伙伴通知策略中需要进一步调查.
评估HIVST的可接受性和可行性,以便在艾滋病毒感染者 (PLHIV) 和关键人群中进行索引测试和通知合作伙伴,对于结束艾滋病流行病至关重要.

研究的目的:

系统地审查有关艾滋病毒自我测试 (HIVST) 的可接受性和可行性的文献,以进行索引测试和通知合作伙伴.
评估基于HIVST的战略的有效性和成本效益,以达到包括关键人群在内的合作伙伴.

主要方法:

按照乔安娜·布里格斯研究所的方法进行了一项混合方法的系统审查.
在四个数据库 (2023年10月至2024年3月) 的文献搜索中,包括了2016年至2023年期间发表的研究.
由于元分析的不可行性,使用了定性元聚合.

主要成果:

在4076项研究中,有76项研究符合纳入标准,主要来自非洲,南亚和东亚的数据有限.
指数HIVST和伴侣测试在PLHIV和关键人群中证明了可接受性和可行性.
辅助合作伙伴通知 (aPN) 证明具有成本效益,尽管诱导比率低,但通知个体的阳性率更高. 对于未婚个人和关键人群的证据有限.

结论:

指数HIVST是可接受的和可行的,以达到指数的合作伙伴,包括从关键人群中未经测试的个人.
进一步研究未婚人群中的HIVST指数和未诊断关键人群的伴侣测试至关重要,特别是在东南亚.
辅助合作伙伴通知 (aPN) 是一种成本效益高的HIV病例检测干预措施.

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