循环休息活动节律与老年痴呆症之间的关联:社区动脉样硬化风险研究
Wendy Wang1,2,3, Amal A Wanigatunga4,5, Lacey H Etzkorn5,6
1Department of Epidemiology, Peter O'Donnell Jr. School of Public Health, UT Southwestern Medical Center, Dallas, TX.
Neurology
|December 29, 2025
概括
较弱和更分散的昼夜休息-活动节奏 (RAR) 和较晚的峰值活动时间与老年人痴呆风险增加有关. 这项研究强调了痴呆症预防策略的潜在目标.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
背景情况:
- 衰老显著改变昼夜节律,影响休息活动模式 (RARs).
- 之前关于昼夜节律和神经认知结果 (包括痴呆症) 的研究,结果各不相同,通常在有限的人群中.
- 了解不同老年人群中的这些关联对于识别痴呆症风险因素至关重要.
研究的目的:
- 研究昼夜休息活动节奏 (RARs) 与患痴呆症的风险之间的关联.
- 在一个种族多样化的老年人群中研究这种关联.
主要方法:
- 对社区动脉样硬化风险研究 (ARIC) 数据的回顾性分析.
- 利用来自Zio XT®补丁的加速度计数据来推导非参数 (相对振幅,日内变化,日间稳定性) 和共 (振幅,比值,) RAR测量.
- 痴呆病例在2020年被裁决; 考克斯比例危险模型被用于分析.
主要成果:
- 较弱的节奏强度 (较低的相对幅度) 和增加的节奏碎片化 (更高的日内变化) 与痴呆的风险显著增加有关.
- 晚期的昼夜定时 () 和节律强度降低 (幅度, mesor) 也与痴呆风险增加相关.
- 这些关联在多变量调整后在多样化的老年人样本中仍然存在.
结论:
- 通过加速度计数据评估的循环节休息活动节奏是老年人痴呆风险的潜在标志物.
- 较弱,更分散的节奏和较晚的活动峰值表明痴呆风险更高.
- 对预防痴呆症的昼夜节律干预措施进行进一步的研究是有必要的.
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