在 Tumor Surgery (PARITY) 随机对照试验中预防性抗生素疗法发表后,临床实践的变化
Samir Sabharwal1, Ricardo G Becker, Michael J Monument
1From the Department of Surgery, Orthopedic Service, Memorial Sloan Kettering Cancer Center, New York, NY (Sabharwal and Morris), the Department of Orthopedics and Trauma, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil (Becker), the Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada (Monument), the Centre for Evidence-Based Orthopaedics, McMaster University, Hamilton, Ontario, Canada (Schneider), the Department of Orthopedic Surgery, Cliniques Universitaires Saint Luc-Institut Roi Albert II, Université Catholique de Louvain, Brussels, Belgium (Schubert), and the Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD (Ghert). Sabharwal is now with the Department of Orthopaedic Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.
在瘤手术中的预防性抗生素疗程 (PARITY) 试验发现,一天的抗生素疗程与骨瘤手术的五天疗程同样有效. 大多数肌肉骨瘤学家都意识到这些发现,并改变了做法,限制了抗生素的使用.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 在外科手术实践中.
背景情况:
- 在瘤手术中预防性抗生素治疗方案 (PARITY) 试验中,对比了1天和5天的术后抗生素治疗方案,用于下肢骨瘤切除和重建.
- PARITY试验没有显示手术部位感染的差异,但在5天的治疗方案中,与抗生素相关的并发症的风险更高.
- 这项研究旨在评估PARITY试验结果对肌肉骨瘤学家临床实践的影响.
研究的目的:
- 评估PARITY试验结果对肌肉骨瘤学家临床实践模式的影响.
- 在发表关于在骨瘤手术中预防性抗生素使用的具有里程碑意义的证据后,确定抗生素处方习惯的变化.
主要方法:
- 一项匿名在线调查于2024年3月在全球范围内分发给肌肉骨瘤学家.
- 该调查探讨了针对PARITY试验结果的实践修改.
- 描述性统计和皮尔森千平方测试用于数据分析.
主要成果:
- 在101名受访者中,93%的人知道PARITY试验的结果.
- 40%的外科医生报告了显著的实践变化,主要是减少了抗生素的持续时间.
- 在PARITY后,将抗生素限制在24小时内的外科医生比例翻了一番,从25%增加到51%.
结论:
- 发表PARITY试验导致了肌肉骨瘤学家在临床实践中的重大转变,趋势是抗生素持续时间更短.
- 影响采用基于证据的实践变化的因素,如个人经验和机构指导方针,需要进一步调查.
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