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通过道化纳米管进行线粒体转移激发了细胞间药物输送的创新策略

Yitian Du¹, Yiwei Peng², Yiliang Yang²

¹Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, PR China.; Inner Mongolia Key Laboratory for Molecular Regulation of the Cell, School of Life Sciences, Inner Mongolia University, 49 Xilin South Road, Yuquan District, Hohhot, Inner Mongolia, 010020, PR China.

Acta biomaterialia

|December 29, 2025

概括

这项研究表明,线粒体可以通过道纳米管 (TNT) 运输药物. 近红外光控制了这一过程,通过调节氧化应激以有效地将药物输送到瘤细胞,使得向癌症治疗成为可能.

科学领域:

生物医学工程生物医学工程
细胞生物学细胞生物学
药物输送系统药物输送系统

背景情况:

固体瘤药物输送面临生物障碍,如密集的细胞外基质和不良血管化.
目前的策略往往侧重于细胞外运输,忽视了关键的细胞内途径.
线粒体和其他生物材料显示出作为生物相容的输送载体的潜力.

研究的目的:

通过道纳米管 (TNTs) 来研究线粒体介导的细胞间传输,用于药物输送.
探索氧化应激在调节TNT形成和线粒体转移中的作用.
开发一种可控制的药物输送系统,使用近红外 (NIR) 光调制TNTs.

主要方法:

使用的线粒体装载有光敏剂IR780 (IR780/Mito) 作为货物.
研究了氧化应激在刺激TNT形成和线粒体转移中的作用.
应用不同强度的NIR光来调节氧化应激和控制TNT动态.
评估了IR780/Mito的细胞间传输和瘤透的效率.

主要成果:

线粒体通过TNT运输,促进细胞间的货物转移.
氧化应激是TNT形成和线粒体运输的关键调节者.
尼尔射线光强度通过调节氧化应激,精确控制TNT的形成和货物运输.
轻度的NIR照射促进了TNT介导的输送到瘤细胞中,而强度照射则阻断了输送.

结论:

TNTs作为有效的细胞内高速公路用于线粒体驱动的药物输送.
通过NIR控制的氧化应激提供了药物运输的时空调节.
这种生物启发的基于线粒体的平台克服了细胞外障碍,提高了治疗效果.
这种方法对精确的癌症治疗和其他涉及细胞间通信的疾病具有前景.

关键词:

灯光操作的调节器.线粒体 - 车 - 车线粒体双向运输是指线粒体双向运输.不通过膜的输送.挖掘纳米管的道

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