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怀孕期间补充维生素B12对早期运动性能的影响. 来自双盲随机对照试验的二次分析
Ingrid Kvestad1, Manjeswori Ulak2, Adrian McCann3
1Regional Centre for Child and Youth Mental Health and Child Welfare, NORCE, Norwegian Research Centre, Bergen, Norway; Women's Clinic, Innlandet Hospital Trust, Lillehammer, Norway.
The Journal of nutrition
|December 29, 2025
概括
母亲补充维生素B12对婴儿的运动技能产生了负面影响,其影响与大多数母亲因素无关. 然而,适当的母体维生素B12状态对婴儿运动发育产生了更明显的负面影响.
科学领域:
- 母婴健康 孕产妇和婴儿健康
- 营养科学 营养科学
- 发育儿科 发育儿科
背景情况:
- 在尼泊尔进行的一项先前随机对照试验 (RCT) 表明,母亲补充维生素B12对婴儿运动性能有不良影响.
- 这项研究调查了基线母体特征是否会改变这种观察到的负面影响.
研究的目的:
- 确定母亲的基线特征,包括维生素B12状态,叶酸,血红蛋白和社会经济地位,是否会改变维生素B12补充剂对婴儿运动发育的影响.
- 分析来自较大的RCT的二次结果.
主要方法:
- 涉及800名怀孕妇女的RCT的二次分析,随机分配给维生素B12或安慰剂.
- 使用婴儿运动性能测试 (TIMP) 评估712名8-12周的婴儿的运动发育.
- 在通用线性模型中,相互作用术语检查了由母体血标记物 (可巴胺,tHcy,MMA,cB12),叶酸,血红蛋白和SES) 修改效应.
主要成果:
- 补充维生素B12对婴儿运动能力的负面影响在大多数子组中一致.
- 血叶酸度是唯一显著改变效果的孕产妇特征 (p=0.015).
- 一个趋势表明,维生素B12在具有足够基线维生素B12和较低叶酸水平的母亲身上具有更强的负面影响.
结论:
- 小组分析没有解释维生素B12补充剂对婴儿运动技能的负面影响.
- 补充维生素B12对婴儿运动性能的负面影响似乎在具有足够基线维生素B12状态的母亲中更为明显.
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