婴儿灵长类动物食叶酸的组织中的叶酸概况
Matthew J Kuchan1, Avinash Pokala1, Stefan Ehling1
1Division of Nutrition, Abbott Laboratories, Columbus, OH.
The Journal of nutrition
|December 29, 2025
概括
组织叶酸度在婴儿身上被探索,揭示了肝脏和脏的最高水平. 叶酸分布在大脑区域之间有所不同,四基叶酸 (THF) 在所有研究的大脑区域中最为丰富.
科学领域:
- 营养科学 营养科学
- 灵长类动物研究研究
- 生物化学 生物化学
背景情况:
- 食叶酸 (FA) 在循环中很常见,但人体组织叶酸的形式和度不明.
- 婴儿 rhesus ,与动物相比,具有较低的 FA 减少活性,作为人类婴儿的相关模型.
- 关于发育中的灵长类动物组织特异性叶酸分布的数据有限.
研究的目的:
- 为了研究婴儿 rhesus macaques 食叶酸的组织叶酸度.
- 为了比较不同婴儿养组之间的不同器官和大脑区域的叶酸水平.
- 为了确定灵长类动物组织中占主导地位的叶酸形式 (四叶酸,5-甲基四叶酸,非代谢叶酸).
主要方法:
- 从母乳/母乳饮食 (BMD) 或牛奶替代品 (MR) 养的婴儿 (n=23) 的档案组织样本的分析.
- 使用LC-MS/MS.量化四基叶酸 (THF),5-甲基四基叶酸 (5-MTHF) 和未代谢的叶酸 (UMFA).
- 血中叶酸的测量,主要器官 (肝脏,脏,心脏,肺) 和多个大脑区域.
主要成果:
- 所有测量的叶酸在组织中检测到,除了THF在血中. 叶酸总度在肝脏和脏中最高,其次是心脏,大脑,肺和血,显示100倍的范围.
- 脏和肺部的非代谢叶酸 (UMFA) 度最高.
- 在大脑内,前额叶和叶皮以及小脑表现出比运动皮层,皮层和条纹体更高的酸盐,THF是所有大脑区域中最丰富的叶酸形式. 养组 (BMD与MR) 在组织和大脑叶酸度上显示出极小的差异.
结论:
- 在不同器官和大脑区域中,组织叶酸代谢,吸收和/或保留的显著变化是有迹象的.
- 需要进一步的研究来阐明这些观察到的叶酸分布模式的基本机制.
- 这些发现有助于理解灵长类动物的叶酸动态,这与人类婴儿的营养和发育有关.
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