基于多糖的可注射水凝用于向药物输送:进展和挑战
Xizhi Liao1, Jiawei Lu1, Jiaxing Yao2
1Hunan Provincial Key Laboratory of Biomass Fiber Functional Materials, School of Packaging Materials and Engineering, Hunan University of Technology, Zhuzhou 412007, China; National & Local Joint Engineering Research Center for Advanced Packaging Material and Technology, Hunan University of Technology, Zhuzhou 412007, China.
International journal of pharmaceutics
|December 29, 2025
概括
天然的多糖化合物形成用于精密医学的注射水凝. 这些生物相容材料为向药物输送提供可调节的特性,增强治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 精准医学需要先进的药物输送平台.
- 来自天然多糖的注射用水凝提供生物相容性和生物降解性.
- 多糖为开发有针对性和受控释放系统而具有多功能.
研究的目的:
- 系统地审查用于注射水凝开发的天然多糖类.
- 为了评估结构特征和设计策略的多糖体水凝注射性.
- 讨论基于水凝的治疗方法的向机制和受控释放策略.
主要方法:
- 对五种主要多糖类的综述:奇托,酸,酸,纤维素和氧化德克斯.
- 基于动态共价交联和物理相互作用的剪切稀释和现场凝结策略的分析.
- 评估液凝的机械性能 (储存模块10^2-10^4Pa) 进行注射.
主要成果:
- 多糖水凝表现出快速凝 (几秒到几分钟) 和可调节的机械强度.
- 讨论了被动和主动准的机制.
- 环境敏感的控制释放是这些水凝的关键特征.
结论:
- 基于多糖的可注射水凝为合理设计提供了一个框架.
- 这些水凝对瘤微环境治疗,慢性疾病治疗,眼部药物输送和感染部位向有前途.
- 该审查促进了有效和精确的药物输送平台的临床转化.
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