基菲提尼布诱导的单边乳头皮肤病:一种不常见的呈现
Priya Yadav1, Shreya K Gowda1, Rhea Ahuja1
1Dermatology and Venereology, AIIMS, New Delhi, India.
BMJ case reports
|December 29, 2025
概括
这项研究报告了一例罕见的晚发,单侧皮疹和指甲炎症病例,该病例发生在为肺癌治疗gefitinib的患者身上. 这种情况,EGFR抑制剂相关的毛囊炎,通过抗生素成功管理,允许继续癌症治疗.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳头发疹是表皮生长因子受体 (EGFR) 抑制剂的常见副作用,通常在治疗的第一个月内出现.
- EGFR抑制剂在治疗转移性非小细胞肺癌 (NSCLC) 中至关重要.
研究的目的:
- 描述一种与EGFR抑制剂相关的皮肤学不良反应的异常晚发,单边呈现.
- 为了突出成功管理这种情况,而不会中断抗癌治疗.
主要方法:
- 一名中年妇女患有EGFR阳性转移性NSCLC,接受gefitinib治疗2.5年的病例报告.
- 临床检查和皮肤活检以诊断喷发.
- 在继续使用gefitinib的同时使用多西环林治疗.
主要成果:
- 经过2.5年的gefitinib治疗后,该患者出现了痛苦的单边乳腺突喷发和.
- 皮肤活检证实了EGFR抑制剂相关的毛囊炎.
- 随着每天两次100毫克的多克西环林,症状显著改善.
结论:
- 可能会出现与EGFR抑制剂相关的皮肤学不良反应 (PRIDE综合征) 的晚发,单边表现.
- 这些表现是可以用抗生素控制的,使得有效的抗癌治疗的继续.
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