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相关概念视频

Membrane Transporters01:31

Membrane Transporters

17.6K
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
17.6K
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

252
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
252
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

40.9K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
40.9K
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

975
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
975
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

243
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
243
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

277
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
277

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相关实验视频

Updated: Jan 7, 2026

Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
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Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes

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简要的药理学指南 2025/26:运输商

Stephen P H Alexander1, Alasdair J Gibb2, Eamonn Kelly3

  • 1Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British journal of pharmacology
|December 29, 2025
PubMed
概括

药理学简要指南2025/26提供了人类药物点及其相互作用的稳定,可引用的记录. 这本两年一次的出版物提供专家策划的药理学工具和命名法,取代了以前的版本.

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 药物发现 药物发现 药物发现
  • 生物医学科学 生物医学科学

背景情况:

  • 英国药理学杂志每两年发布一次对其药理学简要指南的更新.
  • 该指南提供了对药物向家族的比较概述,总结了关键的药理特性.

研究的目的:

  • 提供人类药物点及其相互作用的稳定,可引用,及时记录.
  • 提供专家策划的选择性药理学工具的建议,以确定目标.
  • 提出国际基本和临床药理学联盟 (NC-IUPHAR) 针对药物标的官方分类和命名法.

主要方法:

  • 总结了大约1900个人类药物点和近7000个相互作用的药理学特性.
  • 将来自www.guidetopharmacology.org网站的详细信息凝聚在一个500页的印刷指南中.
  • 将内容分为六个主要的药理目标家族:G蛋白结合受体,离子通道,核激素受体,催化受体,酶和转运体.

主要成果:

  • 2025/26年版总结了大约1900个人类药物点和近7000个相互作用.
  • 它包括命名指南,简要摘要,有关药理工具的信息,关键参考文献和进一步阅读建议.
  • 该指南作为一个永久记录,与不断更新的在线数据库不同.

结论:

  • 药理学简要指南2025/26是研究人员的宝贵资源,提供了对药物标和药理学工具的结构化概述.
  • 它作为一个永久的,可引用的参考,补充了全面的在线数据库.
  • 该出版物确保了药理学研究的标准化命名法和建议.