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相关概念视频

Non-gated Ion Channels01:24

Non-gated Ion Channels

7.9K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.9K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

10.2K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
10.2K
Ion Channels01:19

Ion Channels

91.0K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.0K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

13.9K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
13.9K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.5K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.5K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.6K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.6K

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相关实验视频

Updated: Jan 7, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

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简要的药理学指南 2025/26:离子通道

Stephen P H Alexander1, Jörg Striessnig2, Alasdair J Gibb3

  • 1Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British journal of pharmacology
|December 29, 2025
PubMed
概括
此摘要是机器生成的。

药理学简要指南2025/26提供了药物点及其相互作用的全面概述. 这份两年一次的出版物提供了专家为药理学工具编制的建议,作为药物向信息的稳定,可引用的记录.

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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

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Recapitulation of an Ion Channel IV Curve Using Frequency Components
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Recapitulation of an Ion Channel IV Curve Using Frequency Components

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相关实验视频

Last Updated: Jan 7, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
06:19

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
11:32

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

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Recapitulation of an Ion Channel IV Curve Using Frequency Components
10:14

Recapitulation of an Ion Channel IV Curve Using Frequency Components

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 药物发现 药物发现 药物发现
  • 生物医学科学 生物医学科学

背景情况:

  • 英国药理学杂志每两年出版一次"药理学简要指南".
  • 该指南提供了对药物向家族及其药理学的比较概述.
  • 它是 www.guidetopharmacology.org.org 在线综合数据库的缩写版本.

研究的目的:

  • 提供对人类药物点及其相互作用的清晰,易于访问和结构良好的摘要.
  • 为选择性药理工具提供专家策划的建议.
  • 作为药理信息的永久,可引用,及时记录.

主要方法:

  • 大约1900个人类药物点的关键药理性质的总结.
  • 包含了近7000个相互作用,涉及约4400个连接体.
  • "黄金标准"选择性药理学工具的专家策划.

主要成果:

  • 2025/26年版涵盖了六个主要的药理学目标类别:离子通道,G蛋白合受体,核激素受体,催化受体,酶和输送器.
  • 它包括国际基础和临床药理学联盟 (NC-IUPHAR) 官方的分类和命名,如适用.
  • 提供简要的摘要,有关药理工具的信息,关键参考文献,以及每个目标家族的进一步阅读建议.

结论:

  • 药理学简要指南2025/26是药理学和相关领域的研究人员和科学家的宝贵资源.
  • 它是理解药物标和选择合适的药理学工具的重要参考.
  • 该指南补充了在线数据库,提供了当前药理学知识的稳定,可引用的快照.