母婴皮质醇水平和母亲的童年逆境
Aline Camargo Ramos1,2, Hugo Cogo-Moreira3, Michael Eid4
1Laboratory of Integrative Neuroscience (LiNC), Universidade Federal de São Paulo, Rua Pedro de Toledo 669, 3O. Andar, São Paulo, SP, Brazil.
Scientific reports
|December 29, 2025
概括
孕产妇和婴儿的皮质醇水平显示出早期的同步,随着时间的推移而下降,受到孕产妇的压力和童年经历的影响. 这突显了母亲的逆境对婴儿压力生理学的持久影响.
科学领域:
- 神经内分泌学神经内分泌学
- 发展心理学 发展心理学
- 压力生理学 压力生理学
背景情况:
- 皮质醇是下丘脑-垂体-上腺 (HPA) 轴的关键生物标志物,对压力调节和神经发育至关重要.
- 虽然已知母亲和婴儿皮质醇的联系,但在婴儿早期的同步需要进一步调查.
- 婴儿早期是快速神经内分泌发育和压力系统成熟的关键时期.
研究的目的:
- 在产后早期发育期间检查母亲和婴儿之间的皮质醇合.
- 调查母亲的不良童年经历 (ACE) 和母亲/婴儿皮质醇动态之间的相关性.
- 了解产后1至6个月HPA轴同步的纵向变化.
主要方法:
- 在巴西圣保罗对305个母婴双进行了纵向研究.
- 产后大约1个月和6个月的唾液皮质醇测量.
- 两变的潜变得分建模,以评估内部和个人间的皮质醇动态和合.
主要成果:
- 在1个月 (r=0.319) 和6个月 (r=0.208) 的母亲和婴儿皮质醇之间存在正相关性,表明早期同步减少.
- 在母亲和婴儿中观察到负的自我反:较高的基线皮质醇预测了较小的变化.
- 孕产妇ACE预测了更高的基线孕产妇皮质醇 (B=0.126),但没有影响变化速度.
结论:
- 母婴皮质醇同步存在于婴儿早期,但逐渐脱.
- 由ACEs表示的孕产妇逆境,对产后孕产妇的压力生理有持久的影响.
- 这些发现强调了母体HPA轴调节对婴儿神经内分泌发育的重要性.
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