在不育患者中,单细胞百分比和慢性子宫内膜炎之间的关联:一项回顾性研究
Min Lu1, Xiaoli Sun2
1Department of Gynecology, Guangdong Women and Children Hospital, 521 Xingnan Avenue, Panyu District, Guangzhou, 511400, China.
Scientific reports
|December 29, 2025
概括
单细胞百分比 (MP) 可能有助于预测不育患者的慢性子宫内膜炎 (CE). 较低的MP水平与较高的CE风险相关,表明其作为早期诊断生物标志物的潜力.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科医生 妇科
- 病理学 病理学 病理学
背景情况:
- 慢性子宫内膜炎 (CE) 与不孕不育和植入失败有关,但其临床诊断率很低.
- 单细胞百分比 (MP) 是严重疾病的预后生物标志物,但其在不育患者的CE中的作用尚不清楚.
研究的目的:
- 为了研究单细胞百分比 (MP) 和不孕症患者的慢性子宫内膜炎 (CE) 之间的关联.
- 确定MP是否可以作为早期CE诊断的预测生物标志物.
主要方法:
- 一项对631名被诊断患有CE的患者进行的横截面研究.
- 使用后勤回归分析来评估MP和CE风险之间的相关性.
- 进行了子组和灵敏度分析以证实研究结果.
主要成果:
- 在研究队列中,CE的患病率为78%.
- 单变量和多变量逻辑回归显示了MP和CE风险之间的反相关性 (OR=0.82;95% CI 0.71-0.95).
- 在子组和敏感性分析中观察到一致的结果,证实了这种关联.
结论:
- 单细胞百分比 (MP) 与不孕妇女的慢性子宫内膜炎 (CE) 有显著的关联.
- MP可能是一个有价值和可访问的参数,用于CE的早期预测.
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