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用于预测急性移植排斥的肠道微生物组和代谢物签名:一项前性研究
Hyunjeong Cho1,2, Hoonsik Nam3, Hyo-Eun Kim4
1Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Scientific reports
|December 29, 2025
概括
肠道微生物组的变化或失生症与移植 (KT) 后的急性排斥 (AR) 有关. 这项研究在经历AR的KT患者中发现了特定的微生物和代谢物差异,这表明了改善预测和护理的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 移植科学 移植科学
背景情况:
- 急性排斥 (AR) 是移植 (KT) 后的一个主要并发症.
- 肠道微生物组在调节宿主免疫系统方面发挥着至关重要的作用.
- 了解肠道微生物对AR的影响对于改善移植结果至关重要.
研究的目的:
- 为了调查肠道失调症和AR在脏移植接受者之间的关联.
- 为了确定特定的微生物和代谢特征预测AR.
- 探索临床,微生物和代谢学数据的整合,以提高AR预测.
主要方法:
- 预计将在两个中心招收97名脏移植接受者.
- 在移植前,移植后3个月和12个月的时间点收集便样本.
- 使用16SrRNA测序进行微生物分析和NMR光谱检测用于便代谢.
主要成果:
- 患有AR的患者 (n=33) 显示细菌丰富性和多样性减少.
- 抗逆转录病毒患者表现出埃舍里希亚-希格拉菌的增加和Phascolarctobacterium丰度的减少.
- 代谢学药物在AR患者中显示了较低的和乳酸度,在脂多糖生物合成和短链脂肪酸代谢中发生了改变.
结论:
- 肠道失生症与移植患者的急性排斥有关.
- 特定的微生物和代谢特征可以作为AR的生物标志物.
- 整合临床,微生物和代谢学数据为移植中整体患者管理提供了有前途的方法.
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