孕产妇怀孕中期的饮食模式和来自前性队列研究后代的炎症性肠病
Olivia Mariella Anneberg1, Sjurdur Frodi Olsen2,3, Anne Vinkel Hansen4
1Center for Molecular Prediction of Inflammatory Bowel Disease - PREDICT, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark. omra@dcm.aau.dk.
怀孕期间母亲的饮食会影响孩子的健康. 母亲的多样化饮食与儿童患儿炎症性肠病 (IBD) 的风险显著降低有关.
科学领域:
- 围产期营养学 围产期营养学
- 儿科胃肠病学 儿科胃肠病学
- 免疫系统的发展 免疫系统的发展
背景情况:
- 怀孕期间母亲的饮食会影响后代的免疫系统和肠道微生物群.
- 饮食因素可能会调节患儿炎性肠病 (IBD) 的风险.
研究的目的:
- 调查怀孕期间母亲的饮食模式与子女患儿儿科发病性IBD风险之间的联系.
- 确定特定的孕产妇饮食习惯,可以防止或增加儿童患IBD的风险.
主要方法:
- 使用丹麦国家出生队列 (56,097对母婴对) 的前性队列研究.
- 通过对第二个三个月的食物频率调查问卷数据的k-means集群分析确定了母亲的饮食模式.
- 通过国家卫生登记册确定了儿科发病IBD病例;进行了考克斯回归分析.
主要成果:
- 确定了五种不同的孕产妇饮食模式:多样化,不推,地中海,以动物为基础和西方.
- 与西方模式相比,多样化的母亲饮食模式与儿童发病IBD风险降低45%有关 (HR:0.55;95%CI:0.31-0.97).
- 对于非推的,地中海或以动物为基础的饮食模式,没有发现任何显著的关联.
结论:
- 怀孕期间母亲坚持多样化的饮食模式与儿童发病IBD的风险降低有关.
- 促进多样化的孕产妇营养可能是降低儿童IBD发病率的一种策略.
- 对母亲饮食和后代IBD风险之间的机制进行进一步研究是有必要的.
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