TransBrain:一种计算框架,用于在人类和小鼠之间翻译大脑范围的表型
Shangzheng Huang1,2, Tongyu Zhang1,2, Changsheng Dong1,2
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Nature methods
|December 30, 2025
概括
TransBrain是一个新的计算框架,用于在人类和小鼠之间双向翻译大脑表型. 该工具通过改进同质绘图并使机理学研究成为可能,增强了跨物种大脑研究.
科学领域:
- 神经科学是一个神经科学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 量化跨物种大脑研究受到临床前动物和人类研究之间的挑战的限制.
- 现有的方法缺乏对老鼠和人类大脑结构之间的准确同质映射.
研究的目的:
- 介绍TransBrain,这是一个计算框架,用于在人类和小鼠之间双向翻译大脑范围的表型.
- 为了提高人类-小鼠同质测绘的准确性,并使定量跨物种比较.
主要方法:
- 开发了一个深度神经网络,使用多模式的人类转录学来进行特定区域的皮质和皮质下绘图.
- 使用基于图形的方法构建了一个统一的跨物种表示空间,其中包含了解剖学和连接数据.
- 应用TransBrain评估大脑组织,推断认知功能,并为自闭症研究翻译分子见解.
主要成果:
- 通过使用深度神经网络,在皮质对应方面取得了89.5%的改善.
- 在人类和小鼠皮层中确定了两个进化保守的梯度.
- 在对大脑特征的定量评估,认知功能推断和自闭症机制翻译方面证明了实用性.
结论:
- 跨大脑 (TransBrain) 促进了对大脑功能和组织进行准确,定量,跨物种的比较.
- 该框架允许跨物种对正常和病态大脑功能进行机械研究.
- 通过弥合临床前模型和人类研究之间的差距,TransBrain促进了翻译神经科学的发展.
相关概念视频
00:49The Blood-brain Barrier
Overview
01:30Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).