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在CRBN基板上,PCMT1产生C端周期性伊米德降解

Zhenguang Zhao1, Wenqing Xu1, Ethan Yang Feng1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature chemical biology
|December 30, 2025
PubMed
概括

蛋白质碳氧甲基转移酶 (PCMT1) 通过形成C端周期性胺基来调节大脑细胞 (CRBN) 基质. 这一发现揭示了一条与thalidomide衍生物和CRBN功能相关的新途径.

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