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组织居民耗尽和记忆CD8+ T细胞具有不同的本体,功能和疾病中的作用

Simone L Park1,2, Mark M Painter3,4, Sasikanth Manne3,4

  • 1Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. simone.park@pennmedicine.upenn.edu.

Nature immunology
|December 30, 2025
PubMed
概括

慢性抗原刺激会产生独特的组织内耗尽的CD8+ T (TR-TEX) 细胞,与记忆 (TRM) 细胞不同. TR-TEX细胞独特地预测患者的免疫检查点阻塞反应.

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