行为改变干预措施影响人乳头瘤病毒 (HPV) 疫苗接种的有效性:系统性审查和行为改变分析技术
Harriet Bland1,2, James Harwood3, Jamie Chua4
1Jesus College, University of Oxford, Oxford, UK. harriet.bland@jesus.ox.ac.uk.
BMC cancer
|December 30, 2025
概括
行为干预措施适度地提高了人类乳头瘤病毒 (HPV) 疫苗接种率. 结合特定的技术,比如添加环境对象,显示显著增加,特别是在针对家长时.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 行为科学 行为科学
背景情况:
- 识别有效的行为改变技术 (BCT) 增加人类乳头瘤病毒 (HPV) 疫苗接种在学龄儿童仍然是一个挑战.
- 确定HPV疫苗接种干预措施的最佳目标人群 (青少年,父母/照顾者或两者) 是至关重要的.
研究的目的:
- 评估行为改变干预措施在增加HPV疫苗接种率方面的有效性,与通常护理相比.
- 确定与成功的HPV疫苗接种干预相关的特定BCT和目标人群.
主要方法:
- 对2008年9月至2023年7月期间发表的随机对照试验 (RCT) 进行了中央,Embase,Medline和Eric数据库的系统搜索.
- 使用BCT分类法 (v1) 编码行为改变技术.
- 对基于BCT和干预目标的HPV疫苗接种数据进行了随机效应元分析和子组分析.
主要成果:
- 八个RCT有资格被纳入. 任何行为改变干预都显示了HPV疫苗接种的边界显著增加 (OR 1.2).
- 使用"如何执行行为指令" (BCT 4.1) 和"关于健康后果的信息" (BCT 5.1) 的干预措施没有显著增加吸收率.
- "将物体添加到环境中" (BCT 12.5) 与其他技术的组合显示,HPV疫苗接种率显著增加 (OR 13.6). 仅针对家长/护理人员的干预措施与小幅显著增加有关 (OR 1.3).
结论:
- 这是第一个系统性审查和元分析,量化BCT在增加HPV疫苗接种率方面的有效性.
- 虽然任何行为改变干预都会带来极小的增加,但特定的BCT组合,特别是那些涉及环境修改和针对家长的BCT,显示出更大的希望.
- 针对HPV疫苗接种的公共卫生干预措施应该是具体的,基于证据的,并纳入基于学校的计划,重点是父母的参与.
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