亲炎症状态和代谢失调,将推迟食进展与极度早产婴儿的宫外头部受限生长联系在一起
Chih-Chia Chen1,2, Yung-Chieh Lin2, Cheng-Yang Lee3
1Graduate Institute of Clinical Medicine, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
BMC medicine
|December 30, 2025
概括
在极度早产的婴儿中,延迟食进展与头部生长受限制和神经发育受损有关. 这与炎症和代谢问题有关,这表明一个不成熟的肠-大脑轴起着作用.
科学领域:
- 新生儿科学 新生儿科学
- 神经发育儿科 神经发育儿科
- 围产儿医学 围产儿医学
背景情况:
- 头周长的增长对于婴儿的神经发育结果至关重要.
- 头周长的子宫外生长限制 (EUGR) 与神经发育受损有关.
- 延迟养与极早产婴儿的EUGR之间的关系,特别是关于炎症和代谢失调的关系,需要进一步研究.
研究的目的:
- 调查推迟养进展与极度早产婴儿宫外头部生长限制之间的关联.
- 为了确定是否有助于炎症的状态和代谢失调是这种关联的特征.
主要方法:
- 一项对婴儿出生 ≤28周孕期 (2019-2021) 的队列研究.
- 分析了食进展轨迹 (改善与延迟改善).
- 血代谢量,头部生长和脑部MRI在特定的月经后年龄被评估.
主要成果:
- 哺乳期推迟的婴儿患上胃肠道疾病的比率更高,头周长EUGR的风险增加 (47%对23%).
- 延迟养与头周长三角形z-score低于-1.5 (aOR:5.26) 显著相关.
- 在延迟养组中观察到大脑体积较小和血代谢变化 (炎症标志物升高,氨基酸/卡尼丁代谢物减少).
结论:
- 在极度早产的婴儿中,早期延迟食进展与头部生长受损有关.
- 一种促炎和代谢失调的状态与这种生长障碍有关.
- 这些发现凸显了不成熟的肠-大脑轴在早产婴儿神经发育中的潜在作用.
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