益生菌补充剂对中年和老年轻度认知障碍 (PCAMCI) 的认知和其他与衰老相关的生理功能:随机,三盲,安慰剂受控试验的协议
Jiani Huang1, Quan Zou1, Yue Chen1
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, 130 Dong'an Road, Shanghai, 200032, China.
Nutrition journal
|December 30, 2025
概括
这项研究调查了特定的益生菌是否可以改善轻度认知障碍 (MCI) 的成年人的认知功能. 研究人员将在12个月内跟踪认知,消化和睡眠健康,以了解肠-大脑轴的影响.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 老年学是一门学科.
背景情况:
- 新兴证据通过肠-大脑轴将肠道微生物群与神经认知功能联系起来.
- 初步研究表明,益生菌可能有利于轻度认知障碍 (MCI),但强大的临床试验很少.
- 本协议详细介绍了一项注册的临床试验,以严格评估MCI的向益生菌补充剂.
研究的目的:
- 研究特定益生菌菌株对MCI患者认知功能的影响.
- 探索益生菌补充对与衰老相关的各种生理结果的影响.
- 检查潜在的机制,潜在的肠-大脑轴在认知衰退.
主要方法:
- 一个为期12个月的随机,双盲,安慰剂对照试验,涉及110名患有MCI的参与者 (年龄在55-80岁).
- 参与者接受了益生菌混合物 (Lactiplantibacillus plantarum ST-III,Lacticaseibacillus rhamnosus KF7,Lacticaseibacillus paracasei BD5115) 或马尔托德克斯的安慰剂.
- 主要结局:认知功能 (蒙特利尔认知评估);次要结局:消化,睡眠,与衰老相关的生理标志物,大脑MRI和可穿戴设备数据.
主要成果:
- 关于认知功能变化的初级结果数据正在等待.
- 关于消化健康,睡眠质量和其他生理标志物的二次结果数据正在等待.
- 神经成像和可穿戴设备数据分析正在进行中,以探索机械洞察力.
结论:
- 这项试验预计将为益生菌补充剂如何影响MCI成年人的认知和生理功能提供新的见解.
- 这些发现可能引导肠-大脑轴调节策略的开发,以延缓风险人群的认知衰退.
- 这项研究旨在阐明益生菌影响衰老相关功能的机制.
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