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生命必需品8的DNA甲基化特征及其对痴呆症的影响

David Lukacsovich¹, Liyong Wang^2,3,4, Juan I Young^2,4

¹Division of Biostatistics, Department of Public Health Sciences, University of Miami, Miller School of Medicine, Miami, FL, 33136, USA.

Alzheimer's research & therapy

|December 30, 2025

概括

研究人员确定了与心血管健康得分 (Life's Essential 8) 相关的DNA甲基化生物标志物,这些生物标志物可以预测痴呆风险. 这些发现表明痴呆症预防策略的潜在目标.

科学领域:

表观遗传学和神经退行性疾病研究
心血管健康和痴呆症之间的联系

背景情况:

痴呆症患病率的增加需要有效的预防策略.
反映痴呆风险生活方式因素的客观生物标志物有限.
较低的生活必需品8 (LE8) 评分与痴呆症风险增加相关.

研究的目的:

为了识别与LE8分数相关的DNA甲基化生物标志物.
研究这些生物标志物对痴呆风险的相关性.

主要方法:

来自北曼哈顿研究 (NOMAS) 的273名西班牙裔成年人 (年龄≥40) 的全表观基因组关联研究 (EWAS).
使用Illumina MethylationEPIC阵列进行评估的DNA甲基化 (DNAm).
确定与LE8相关的CpG和差异甲基化区域 (DMR),然后进行功能和整合分析.

主要成果:

经过调整后,11个CpG和37个DMR显示与LE8有暗示的关联.
与LE8相关的位点映射到参与血管完整性和炎症的基因/通路.
在HOXA5基因促进体中的CpG显示了作为潜在的痴呆症生物标志物的收证据,包括血脑DNAm相关性.

结论:

与LE8相关的DNA甲基化位点将心血管健康与痴呆风险联系起来,提供潜在的预防目标.
DNAm生物标志物可以客观地识别高风险个体并监测干预反应.
为了临床应用,需要在不同的队列中进一步验证.

关键词:

通过DNA甲基化.痴呆症是一种痴呆症.全表观基因组协会研究研究.生命的必需品 8

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