用secukinumab治疗的患者的结核病发病率 - 巴西的一项现实研究
Felipe Merchan Ferraz Grizzo1, Sineida Maria Berbert Ferreira2, Maria Victória Suárez Restrepo3
1Rheumatology Service, Parana Medical Research Center, PMRC, Av. Carlos Correa Borges, 933 - Zona 05, Maringá, Paraná, 87060-000, Brazil. felipegrizzo@gmail.com.
Advances in rheumatology (London, England)
|December 30, 2025
概括
这项研究在巴西患者中没有发现结核病 (TBD),这些患者患有牛皮 (PsO),轴性脊椎关节炎 (axSpA) 或牛皮性关节炎 (PsA),接受了secukinumab治疗. 大多数患者在治疗后仍然没有结核感染 (TBI),这表明了有利的安全概况.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
背景情况:
- 结核病 (TB) 构成了重大的全球卫生挑战,特别是在低收入和中等收入国家.
- 瘤坏死因子α (TNFα) 抑制剂虽然对慢性炎症性疾病如牛皮 (PsO),轴性脊柱关节炎 (axSpA) 和牛皮性关节炎 (PsA) 有效,但存在增加结核病风险的担忧.
- 与较新的生物疗法 (如IL-17抑制剂) 相关的结核病风险数据仍然有限.
研究的目的:
- 评估使用secukinumab治疗的巴西患者的肺结核病 (TBD) 发生率,这些患者患有PsO,axSpA和PsA.
- 评估secuquinumab在这个患者群体中的结核病风险的真实安全性.
主要方法:
- 采用了现实世界的回顾性研究设计.
- 包括152名巴西患者,年龄≥18岁,接受治疗至少24个月,没有先前的结核病诊断.
- 从医疗表中收集数据,对患者人口统计,并发病,疾病特征和sequinumab治疗细节进行描述性分析. 结核感染 (TBI) 检测也受到监测.
主要成果:
- 在40.1个月的平均随访期间,没有记录结核病 (TBD) 病例.
- 研究群体主要包括PsA患者 (n=90),平均年龄为52岁,轻微男性占主导地位 (50.7%).
- 虽然一些患者的结核感染 (TBI) 检测呈阳性,并接受了预防性治疗,但大多数患者在治疗后仍然呈阴性.
结论:
- 在这个巴西队列中,secukinumab治疗与没有观察到结核病病例有关.
- 这些发现表明,在患有PsO,axSpA和PsA的患者中,secukinumab对结核病风险的安全性概况可能是有利的.
- 建议进行进一步的研究,以扩大对接受这些疾病治疗的患者结核病预防策略的理解.
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