根据MIMIC-IV数据库的数据,低温与患有败血症的重症患者的全因死亡率有关
Jinmin Chen1, Wenyuan Zhang2, Yongmei Yang3
1Department of Emergency Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Scientific reports
|December 30, 2025
概括
败血症患者的低温或低体温与更高的死亡风险有关. 这项研究强调了重症监护室 (ICU) 温度管理的关键需求,以改善败血症的结果.
科学领域:
- 关键护理医学 关键护理医学
- 败血症病理生理学病理生理学
- 热调节 热调节 热调节
背景情况:
- 在败血症患者中,温度波动很常见.
- 败血症中低温的预后意义需要进一步调查.
研究的目的:
- 为了确定低温和败血症患者的死亡率之间的关联.
- 评估低温对败血症结果的影响.
主要方法:
- 使用了密集护理IV (MIMIC-IV) 数据库的医疗信息中心.
- 包括19,636名败血症患者,其中937人 (4.8%) 在ICU入院后24小时内出现低温.
- 使用多变量考克斯回归,倾向得分匹配 (PSM) 和治疗权重的逆概率 (IPTW) 进行分析.
主要成果:
- 低温与180天和360天死亡率的增加显著相关 (P < 0.001).
- 在匹配和加权的队列中,研究结果一致,证实了关联的稳定性.
- 患有低温症的患者与没有低温症患者相比,死亡率更高.
结论:
- 败血症患者的低温是增加住院和全因死亡率的重要预测因素.
- 强调在ICU中维持正常热量对于败血症管理至关重要.
- 温度监测和干预对于改善败血症患者的存活率至关重要.
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