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OATP2B1 缺陷改善了因虹素诱导的胃肠道毒性

Hanieh Taheri1, Peter de Bruijn2, Yang Li1

  • 1Division of Pharmaceutics and Pharmacology, College of Pharmacy, the Ohio State University, Columbus, Ohio, USA.

Clinical and translational science
|December 30, 2025
PubMed
概括

有机阴离子运输多OATP2B1调解了SN-38的肠道吸收,SN-38是虹色素的代谢物 (CPT-11). 缺少OATP2B1会减少CPT-11的胃肠道毒性,这表明OATP2B1的抑制是一种治疗策略.

关键词:
CPT-11,这是一个很好的方法.这是一个OATP2B1B1的OATP2B1B1.腹 腹 腹 腹 腹 腹毒品运输商 毒品运输商氨酸的作用: 氨酸的作用是:

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