多焦点/多中心乳腺癌的临床病理学特征和预后分析
Jiaxin Zhang1,2, Hong Fang3, Ziwei Zhao3
1Department of Breast Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Scientific reports
|December 30, 2025
概括
多焦点/多中心乳腺癌 (MMBC) 患者与单焦点乳腺癌 (UFBC) 患者相比,表现出明显的临床病理特征. 虽然无病生存率没有显著差异,但MMBC的总生存率较差,需要量身定制的治疗策略.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 多焦点/多中心乳腺癌 (MMBC) 在诊断和治疗方面存在独特的挑战.
- 了解其临床病理特征和预后影响对于患者管理至关重要.
研究的目的:
- 为了比较MMBC与单焦乳腺癌 (UFBC) 的临床病理特征和生存结果.
- 确定影响MMBC患者预后的独立风险因素.
主要方法:
- 对262名MMBC患者和1,745名UFBC患者的临床病理学数据的回顾性分析.
- 生存分析,包括无病生存率 (DFS) 和整体生存率 (OS).
- 多变量分析以确定独立的预后因素.
主要成果:
- 与UFBC相比,MMBC患者更年轻,更有可能进入更年期前,患有"其他类型的侵入性癌症",负HER2表达和缺乏神经入侵的比率更高.
- 在MMBC和UFBC组之间的DFS没有显著差异 (P=0.199).
- 在OS (P=0.003) 中的统计学显著差异,由于淋巴结转移和瘤负担较高,MMBC可能具有较差的结果.
- 更年期和临床阶段III是DFS的独立风险因素;更年期是MMBC中OS的独立风险因素.
结论:
- 与UFBC相比,MMBC具有明显的临床病理特征,影响了预后差异.
- 更年期状态和晚期临床阶段是MMBC患者的关键预后指标.
- 建议对MMBC患者进行个性化治疗方法,特别是那些经过更年期或疾病已晚期的患者.
更多相关视频
相关概念视频
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
01:21Cancer Survival Analysis
626
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
626