氧化应激,高氧/低氧和新生儿呼吸系统疾病
Ourania Kaltsogianni1,2, Theodore Dassios1,2, Anne Greenough1,2
1Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RJ, UK.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
过早出生的婴儿面临高氧化应激,增加呼吸系统疾病的风险,如BPD. 优化氧气输送可以减少这种压力并改善结果.
科学领域:
- 新生儿医学 新生儿医学
- 儿科肺病学 儿科肺病学
- 生物化学 生物化学
背景情况:
- 过早出生的新生儿具有有限的抗氧化能力,使他们容易受到围产期氧化应激.
- 氧化应激与主要的新生儿疾病有关,包括呼吸困扰综合征 (RDS),支气管肺功能障碍 (BPD) 和肺高血压 (PH).
- 在早产婴儿中,低氧和高氧暴露会加剧氧化应激和相关疾病.
研究的目的:
- 审查氧化应激,氧气变化 (低氧/高氧) 和新生儿呼吸道疾病之间的复杂关系.
- 综合当前对氧化压力如何影响新生儿呼吸系统疾病的发展和进展的理解.
主要方法:
- 这篇叙述性综述综合了临床前和临床研究的发现.
- 文献搜索的重点是氧化应激生物标志物,抗氧化酶活性和早产婴儿患有呼吸系统问题的氧气暴露影响.
主要成果:
- 患有RDS和BPD的早产婴儿表现出高氧化应激标志物和降低抗氧化酶活性.
- 间歇性低氧化与BPD的发展有关,而高氧化暴露与长时间的呼吸支和增加的BPD率相关.
- 临床前证据表明缺氧和高氧导致PH,高氧可能会损害肺血管扩展剂的有效性.
结论:
- 目前的抗氧化剂疗法由于适度的疗效和安全性问题而缺乏常规的临床实施.
- 优化氧气的管理,可能使用自动闭环系统,提供了一个有希望的策略,以减轻新生儿的氧化应激.
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