作为辐射剂量测量和健康风险评估的生物标志物的核因子红色素2-相关因子2 (NRF2):一篇评论
Kave Moloudi1,2,3, Traimate Sangsuwan2,3, Satoru Monzen4
1Laser Research Centre, Faculty of Health Sciences, Doornfontein Campus, University of Johannesburg, Johannesburg 2028, South Africa.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
核因素红色素2相关因子2 (NRF2) 显示为评估辐射暴露的生物标志物具有前途. 它的激活模式有助于评估氧化应激和潜在的健康风险,特别是在较低剂量时.
科学领域:
- 放射生物学的放射生物学
- 分子生物学分子生物学
- 生物标志物研究 生物标志物研究
背景情况:
- 核因素红色素2相关因子2 (NRF2) 调节对氧化应激的抗氧化反应.
- 电离辐射 (IR) 暴露会触发活性氧物种 (ROS),影响NRF2通路.
- 导致细胞保护性基因表达的NRF2激活是细胞对IR的关键反应.
研究的目的:
- 审查NRF2作为放射生物剂量测量的补充生物标记物的新兴作用.
- 评估NRF2在评估辐射暴露和相关健康影响方面的潜力.
- 将NRF2与现有的生物对比生物标志物进行比较,并讨论其优势和局限性.
主要方法:
- 文献综述检查NRF2对电离辐射的反应.
- 与辐射剂量和时间相关的NRF2表达模式的分析.
- 将NRF2与辐射生物测量中的其他生物标志物进行比较.
- 介绍一种放射生物模型,用于低剂量对NRF2的IR影响.
主要成果:
- NRF2水平以剂量和时间依赖的方式增加,特别是在低到中等辐射剂量时.
- 高剂量的辐射 (>8 Gy) 可能会由于亡或损伤抑制NRF2激活.
- NRF2提供了诸如灵敏度和早期反应等优势,但具有局限性,包括高剂量可变性.
结论:
- 在评估辐射暴露和为辐射保护策略提供信息方面,NRF2显示出显著的前景.
- 了解NRF2表达模式可以提高对剂量依赖氧化应激机制的了解.
- 除了生物对称,NRF2在炎症和一般健康风险评估方面具有更广泛的应用.
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