Nrf2作为IBD中氧平衡和屏障完整性的分子守护者
Bojan Stojanovic1,2, Ivana Milivojcevic Bevc3, Milica Dimitrijevic Stojanovic2,4
1Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
核因素红色素2相关因子2 (Nrf2) 在控制炎症性肠病 (IBD) 中的氧化应激和炎症方面发挥着关键作用. 针对Nrf2为IBD患者提供了有前途的治疗策略.
科学领域:
- 胃肠道学和免疫学
- 分子生物学分子生物学
- 转毒生物学 转毒生物学
背景情况:
- 炎症性肠病 (IBD) 涉及慢性胃肠炎症,免疫失调,氧化应激和屏障功能障碍.
- 氧化应激,以反应性氧物种 (ROS) 积累为标志,对IBD病原有显著贡献.
- 核因子红色素2相关因子2 (Nrf2) 是一个关键的转录因子,调节细胞防御氧化应激和炎症.
研究的目的:
- 审查氧化应激在IBD中的病原性作用.
- 阐明Nrf2激活减轻IBD相关损伤的机制.
- 探索针对Nrf2治疗IBD的治疗策略.
主要方法:
- 对IBD中氧化应激和Nrf2研究的文献综述.
- 对Nrf2调节的分析 (Keap1依赖和独立通路).
- 检查Nrf2对上皮质完整性,免疫细胞,微生物群和IBD并发症的影响.
主要成果:
- 氧化应激通过ROS积累和障碍屏障功能受损而加剧IBD.
- Nrf2激活会对抗ROS,促进上皮的修复,并影响免疫细胞的两极分化.
- Nrf2在IBD相关的瘤发生和纤维化中起着复杂的作用.
- 通过药物,饮食或益生菌进行Nrf2调节显示出治疗潜力.
结论:
- Nrf2是粘膜平衡的中央调节者,也是IBD的关键参与者.
- 准Nrf2通路代表了IBD的一个有前途的治疗途径.
- 调节Nrf2可以恢复上皮的弹性,并减少IBD的炎症.
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