酸酸,一种来自Hyssopus cuspidatus Borris的新型酸,通过Keap1相互作用保护肝细胞免受氧化损伤
Xingyu Liu1,2, Zhao Zhang1, Denghui Gao3
1National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130117, China.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
一种新型的酸,酸酸 (CuF),通过减少氧化应激和肝细胞中的脂质积累来对抗代谢功能障碍相关的性肝病 (MASLD). CuF激活抗氧化途径,显示作为天然药物候选者的潜力.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 代谢功能障碍相关的性肝病 (MASLD) 的发病包括脂毒性和氧化应激.
- 目前的MASLD治疗方法有限,需要新的治疗策略.
- 一种新的化合物,酸酸 (CuF),是从Hyssopus cuspidatus*中分离出来的.
研究的目的:
- 为了研究CuF对自由脂肪酸 (FFA) 诱导的肝细胞损伤的治疗潜力.
- 阐明CuF对氧化应激和脂质积累的影响的分子机制.
主要方法:
- 使用暴露于FFA的HepG2细胞以模拟MASLD *在体外*.
- 评估了细胞内活性氧物种 (ROS),脂质积累 (总胆固醇和甘油三水平) 和抗氧化酶活性 (SOD,CAT).
- 采用分子对接和毛细血管电泳来分析CuF与Keap1-Nrf2通路的相互作用.
主要成果:
- 暴露于FFA显著增加了HepG2细胞中的ROS和脂质积累.
- CuF治疗逆转了FFA诱导的ROS和脂质积累的增加.
- 通过破坏Keap1-Nrf2复合体,CuF使抗氧化酶活性正常化,并促进了Nrf2核转位.
结论:
- 在体外*中,CuF显示出显著的抗氧化和抗脂毒作用.
- CuF的机制涉及激活Nrf2抗氧化途径.
- 这种新的酸代表了对MASLD的有希望的基于天然产品的治疗候选者.
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