预防aminoglycoside诱导的耳毒性的实验和临床方法:一个范围审查
Marek Zadrożniak1, Maciej Biskupski2, Marcin Szymański1
1Department of Otolaryngology, Head and Neck Surgery, Medical University of Lublin, 20-090 Lublin, Poland.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
氨基甘油酸抗生素可以导致听力损失. 本综述绘制了预防这种耳毒性的策略,发现了有希望的临床前结果,但对许多干预措施的临床证据有限,不一致.
科学领域:
- 耳毒性和药理学 耳毒性和药理学
- 药物安全与治疗学
背景情况:
- 氨基糖化物是必需的抗生素,但会导致无法逆转的听力损失.
- 预防氨基糖化物诱导的耳毒性是一种至关重要的未满足的医疗需求.
研究的目的:
- 系统地审查和绘制实验和临床策略,以预防氨基糖化物诱导的听力损失.
- 整合来自临床前和转化研究的机制性见解.
主要方法:
- 在体外,体内和临床研究的范围审查.
- 对抗氧化剂,线粒体和通道阻断策略的临床前证据的分析.
- 对药理干预的临床数据的评估.
主要成果:
- 临床前研究表明抗氧化剂,线粒体稳定和通道阻断剂具有前景.
- 临床证据有限且多样化;阿司匹林显示强大的保护 gentamicin 耳毒性.
- N-乙-L-氨酸 (NAC) 提供了特定人群的好处,而维生素E没有显示出临床疗效.
结论:
- 强有力的临床前数据支持药理性自身保护机制.
- 临床研究很少,功能不足,不一致.
- 需要有机理的,充足的临床试验来将研究结果转化为实践.
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