发酵酵母复杂提取物通过减少氧化应激减轻头发的生长,促进头发的再生
Kyung-A Byun1,2, Chang Hu Choi3, Seyeon Oh2,4
1Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
发酵酵母复合提取物 (FYCE) 通过减少氧化应激和炎症来促进头发的再生. 这种生物活性成分激活抗氧化途径并抑制炎症信号,支持毛囊再生并增加毛发数量.
科学领域:
- 皮肤病学和头发生物学
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 头发生长依赖于皮肤乳头细胞 (DPC) 调节的循环,但氧化应激和炎症破坏了这一过程.
- 发酵酵母复合提取物 (FYCE),富含像GABA这样的抗氧化剂,为缓解这些干扰提供了潜在的潜力.
研究的目的:
- 调查FYCE在促进头发再生的有效性.
- 阐明FYCE在DPC中对氧化应激和炎症通路的作用机制.
主要方法:
- 评估FYCE对过氧化处理DPC中的NRF2,NF-κB和NLRP3炎症体的影响.
- 评估FYCE对生长因子 (IGF-1,Wnt10b,Wnt3a) 和β-catenin稳定性的影响.
- 检查FYCE对剃须动物皮肤模型中毛囊数量和异质相的影响.
主要成果:
- FYCE显著上调NRF2 (3.2倍) 和IGF-1 (5.4倍),同时降低NF-κB (0.6倍) 和NLRP3炎症组分.
- FYCE增加了Wnt10b (1.8倍),Wnt3a (2.9倍),并稳定了β-catenin (2.8倍).
- 在体内研究表明,FYCE增加了毛囊数量 (1.6倍),并促进了亚原阶段 (3.0倍).
结论:
- 通过调节抗氧化和抗炎途径,FYCE促进头发的再生.
- FYCE的机制涉及NRF2激活,NF-κB抑制和NLRP3炎症酶下调.
- 作为预防和逆转脱发的治疗剂,FYCE显示出前景.
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