利科通过向ERK通路来保护脱氧尼瓦诺诱导的肠壁功能障碍和NLRP3炎症酶激活
Zihui Cai1, Zhi Lu2,3, Youshuang Wang1
1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China.
Antioxidants (Basel, Switzerland)
|December 30, 2025
概括
百合素 (LYC) 通过减少炎症和氧化应激来保护免受脱氧 (DON) 诱导的肠损伤. LYC针对ERK通路,为DON相关的肠毒性提供了潜在的治疗策略.
科学领域:
- 农业科学 农业科学
- 毒理学 毒理学 毒理学
- 营养科学 营养科学
背景情况:
- 脱氧尼瓦伦醇 (DON) 是一种常见的谷物污染物,会导致肠道损伤和免疫毒性.
- 利科 (LYC) 是一种来自番茄的抗氧化剂,具有抗炎性质和潜在的健康益处.
研究的目的:
- 为了研究Lycopene (LYC) 对肠道细胞中由deoxynivalenol (DON) 诱导的肠毒性产生的保护作用.
- 阐明LYC对DON暴露的保护作用背后的分子机制.
主要方法:
- IPEC-J2细胞暴露于DON (0.5微米) 和/或LYC (30微克/毫升).
- 评估了肠道屏障功能,氧化应激标志物,促炎细胞因子 (TNF-α,IL-1β,IL-18,IL-6),IL-10和NLRP3炎症酶激活.
- 研究了MAPK/NF-κB通路和ERK激活剂 (4-MBC) 的作用.
主要成果:
- 暴露于DON会损害肠道屏障功能,诱导氧化应激,并促进促炎性细胞因子分泌.
- DON通过MAPK/NF-κB通路激活了NLRP3炎症体.
- LYC治疗逆转了DON诱导的细胞损伤,炎症和氧化应激.
- 由于ERK激活剂4-MBC减少了LYC的保护作用,这表明ERK通路参与.
结论:
- 莱科 (LYC) 有效地保护肠道细胞免受脱氧尼瓦伦醇 (DON) 诱导的肠毒性和炎症.
- 该ERK通路是LYC对DON诱导的肠壁功能障碍的保护作用的关键调解者.
- 在农业环境中,LYC是减轻DON毒性的潜在治疗剂.
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