染色体黑斑与儿童牙之间的关联:系统性审查和元分析
Carla Borrell-Garcia1, Paula Boo-Gordillo1, Clara Guinot-Barona1
1Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain.
Children (Basel, Switzerland)
|December 30, 2025
概括
儿童的黑色斑点 (BS) 似乎与牙损风险降低有关. 然而,这种关联需要谨慎解释,因为研究有限,研究结果显著异质.
科学领域:
- 儿科牙科 儿科牙科
- 口腔健康研究研究 口腔健康研究
背景情况:
- 在儿童的牙上观察到染色黑色污点 (BS).
- 在儿童群体中,BS和牙 (腔) 之间的关系需要进一步阐明.
研究的目的:
- 系统地评估黑色斑点与儿童牙之间的关联.
- 为了确定儿童群体中黑色斑点的综合患病率.
主要方法:
- 在主要数据库 (PubMed,科学网,EMBASE,科克兰图书馆) 进行了全面的系统搜索.
- 包括的研究包括观察设计,临床试验和系统性审查,重点是15岁以下的儿童.
- 随机效应的元分析被用来计算空风险和BS流行率的合并几率比率,使用纽卡斯尔-太华尺度评估质量.
主要成果:
- 在包括的14项研究中,有12项表明BS与牙损伤之间存在逆相关性.
- 五项研究的元分析显示,BS儿童患病的几率明显降低 (合并OR=0.53;95%CI:0.36-0.78).
- 总体汇总的BS患病率估计为9.4% (95% CI:6.6-12.2%),在研究中观察到相当大的异质性.
结论:
- 儿童的黑色斑点可能与牙损风险降低有关.
- 由于研究数量有限和显著的异质性,这种潜在的保护性关联需要进一步调查.
- 未来的研究应该旨在澄清机制,并在更大,更统一的儿科队伍中证实研究结果.
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