长期COVID流行和风险因素:对前性队列研究的系统审查和元分析
Ramona-Georgiana Halas1, Delia Mira Berceanu Vaduva2, Matilda Radulescu3
1Doctoral School, Department of General Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Biomedicines
|December 30, 2025
概括
长期COVID影响了大约18%的SARS-CoV-2幸存者,疲劳和呼吸短促是常见的. 感染期间的女性性和住院是发展长期COVID的关键风险因素.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 长期COVID (SARS-CoV-2感染的急性后续) 影响全球数百万人,影响生活质量.
- 持续的症状需要了解患病率和风险因素.
研究的目的:
- 进行前性队列研究的元分析.
- 为了估计长期COVID症状的患病率.
- 为了确定与长期COVID相关的风险因素.
主要方法:
- 在PubMed的系统文献搜索中寻找前性队列研究 (2020-2025).
- 纳入标准: ≥100名参与者,≥3个月的随访时间.
- 随机效应模型用于聚合流行率和赔率比率;使用NOS评估偏差风险.
主要成果:
- 分析了14项研究 (n=168,679);综合长期COVID流行率为18.0% (≥6个月随访).
- 最常见的症状:疲劳 (41.0%) 和呼吸障碍 (22.5%).
- 确定了重要的风险因素:女性性别 (OR=1.52) 和先前住院治疗 (OR=2.35).
结论:
- 长期COVID影响了超过五分之一的SARS-CoV-2幸存者.
- 疲劳和呼吸障碍是普遍存在的持续症状.
- 女性性别和严重的急性感染与风险增加有关;建议标准化定义和更长的随访.
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