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计算流体动力学分析破裂和内动脉瘤生长的方法:一个系统的审查

Vincenzo T R Loly¹, Arthur Cintra¹, Felipe Ramirez-Velandia²

¹Hospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.

|December 30, 2025

概括

本综述强调了使用计算流体动力学 (CFD) 进行内动脉瘤 (IA) 破裂风险评估的关键血液动力学和形态学参数. 标准化CFD方法对于IA增长和断裂预测的临床转化至关重要.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
流体动力学流体动力学

背景情况:

血液动力学压力因素,如异常的壁切应力和振荡式切索指,都与内动脉瘤 (IA) 发病,生长和破裂有关.
计算流体动力学 (CFD) 是在IA中对这些血液动力学因素进行定量评估的重要工具.

研究的目的:

系统地审查最近对人类囊动脉瘤的CFD研究.
识别经常分析的血液动力学和形态学参数.
要总结这些CFD分析中使用的方法论策略.

主要方法:

按照PRISMA指南 (2019-2024) 进行系统审查.
在PubMed,Scopus,Web of Science和Embase数据库中进行了搜索.
包括使用CFD对与破裂或生长相关的人类囊动脉瘤的研究,不包括理想化的模型和非人类分析.

主要成果:

35项研究符合标准;商业软件主导了CFD流程.
经常分析的血液动力学参数:振荡切削指数 (OSI,91.43%),时间平均壁切削应力 (TAWSS,71.43%),低切削面积比率 (LSAR,60.00%),正常化壁切削应力 (NWSS,51.43%) 和相对停留时间 (RRT,45.71%).
关键的形态参数:视角比 (AR,74.29%),尺寸比 (SR,68.57%) 和体积 (42.86%) 与IA破裂和生长有很强的关联.

结论:

一组核心参数 (AR,SR,TAWSS,OSI,RRT,LSAR) 一致地预测IA破裂和增长.
方法的多样性和缺乏统一的标准阻碍了可复制性和临床翻译.
计算框架,参数定义和边界条件的标准化对于CFD在IA风险评估中的临床适用性是迫切需要的.

关键词:

在 CFD 交易中,我们可以看到 CFD.动脉瘤生长的增长血液动力学血液动力学头骨内动脉瘤是什么意思形态参数形态参数破裂的风险破裂的风险

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