晚期皮肤状细胞癌:生物学,免疫疗法和不断变化的预后因素
Antonio Di Guardo1,2, Federica Trovato1,2, Carmen Cantisani1
1Unit of Dermatology, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Biomedicines
|December 30, 2025
概括
使用PD-1阻断治疗的高级皮肤状细胞癌 (aCSCC) 治疗显示出45-60%的应答率. 需要进一步的研究来个性化管理异质患者的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 先进的皮肤状细胞癌 (aCSCC) 呈现出显著的发病率和死亡率.
- 目前的全身治疗方法,特别是免疫检查点抑制剂,提供治疗效益,但结果异质.
研究的目的:
- 审查aCSCC的流行病学,生物学,临床表现和分期.
- 批判性地评估治疗策略,重点关注编程死亡1 (PD-1) 封锁.
- 确定预后决定因素,并概述个性化管理的优先事项.
主要方法:
- 对aCSCC当前知识的叙述性回顾.
- 对PD-1阻断的临床试验和观察研究的评估.
- 综合有关预后因素和未来研究方向的数据.
主要成果:
- 免疫检查点抑制剂 (PD-1阻塞) 是aCSCC的主要全身治疗方法,反应率为45-60%.
- 一部分患者经历了持续的益处,与可管理的免疫相关毒性有关.
- 结果的异质性值得注意,特别是在脆弱的患者群体中.
结论:
- 阻断PD-1代表了aCSCC系统治疗的重大进展.
- 既定和新出现的预后因素需要进一步调查风险分层.
- 基于生物标志物的研究和现实世界的注册对于个性化,多学科的aCSCC管理至关重要.
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