赫斯佩里丁通过调节抗氧化剂,长寿和衰老相关基因来逆转氧化应激诱导的细胞损伤
Supansa Buakaew1, Chadamas Sakonsinsiri1, Worachart Lert-Itthiporn1,2
1Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Biomedicines
|December 30, 2025
概括
黑斯匹里丁治疗可以通过增强抗氧化基因,如超氧化物转化酶 (MnSOD) 和素1 (SIRT1) 等抗氧化基因,从而逆转细胞的氧化损伤,同时减少细胞衰老. 这表明hesperidin可能会预防慢性病 (CKD).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 氧化应激,氧化剂和抗氧化剂之间的不平衡,损害生物分子,并导致衰老和慢性病 (CKD).
- 类植物中的一种类黄素hesperidin具有抗氧化和抗炎性质,但其对逆转细胞氧化损伤的影响尚不清楚.
研究的目的:
- 为了研究hesperidin的潜力逆转过氧化 (H2O2) 诱导的氧化损伤在人类脏近接管状上皮 (HK-2) 细胞.
主要方法:
- HK-2细胞暴露于H2O2以诱导氧化应激.
- 随后,细胞被用hespéridine处理.
- 评估了关键基因表达 (MnSOD,SIRT1,β-galactosidase) 和细胞毒性.
主要成果:
- 赫斯佩里丁显著降低了H2O2诱导的HK-2细胞中的细胞毒性.
- 用hesperidin进行后期治疗可提高抗氧化基因超氧化失调酶 (MnSOD) 和长寿基因sirtuin 1 (SIRT1) 的调节.
- 赫斯佩里丁治疗降低了衰老标志物β-galactosidase的调节.
结论:
- 素通过增强抗氧化剂和长寿途径,促进氧化性细胞损伤的恢复.
- 素减少细胞衰老,这表明它可能在改善脏健康方面发挥作用.
- 这些发现表明,hesperidin可能有助于减缓患有氧化应激相关损伤的患者的CKD进展.
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