长期COVID和牙周病发展或进展之间的生物学合理性
Oelisoa Mireille Andriankaja1, Sidney Whiteheart2, Marcelo Barbosa de Accioly Mattos3
1Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40508, USA.
Biomedicines
|December 30, 2025
概括
长期COVID (LC) 可能会增加患有牙周炎的风险,原因是共享的免疫炎症通路和潜在的口腔微生物组变化. 需要进一步的研究来证实长期COVID和牙疾病之间的这种联系.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 传染病免疫学 传染病免疫学
- 系统健康 系统健康
背景情况:
- 长期COVID (LC) 是一种多系统性疾病,在SARS-CoV-2感染后出现持续症状.
- 口腔对SARS-CoV-2的敏感性表明可能与牙周健康有关.
- 了解这种联系对于全面的患者护理至关重要.
研究的目的:
- 探索长期COVID对牙周健康的潜在影响.
- 审查现有的关于LC和口腔疾病之间的相互作用的文献.
- 确定这个新兴领域的未来研究方向.
主要方法:
- 在PubMed中使用LC和牙周病的关键词进行了全面的文献搜索.
- 文章被过为2019-2024年的英语全文出版物.
- 该审查包括了有关病原,免疫机制,微生物组变化和临床结果的研究.
主要成果:
- 乳腺癌涉及系统性免疫炎症失调,与牙周炎机制重叠.
- 在LC期间肠道和肺部微生物组的变化可能会影响口腔微生物群落.
- 牙细胞中的ACE2表达和病毒再激活将牙细胞与牙周炎病原体联系起来.
结论:
- 长期的COVID可能成为牙周炎的全身风险因素.
- 本综述为LC与口腔健康的相互作用建立了理论基础.
- 进一步的流行病学和机制学研究对于阐明这些关系至关重要.
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