在分化甲状腺癌中进行手术内粗甲状腺外延伸 (T3b) 评估的准确性和临床意义
Solji An1, Joonseon Park1, Kwangsoon Kim1
1Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Cancers
|December 30, 2025
概括
在甲状腺癌分期内对粗甲状腺外延伸 (ETE) 的术内评估是主观的. 虽然复发率相似,但准确的T3b分期可能会影响无复发生存率,这需要进一步调查.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 甲状腺癌研究研究
背景情况:
- 美国癌症联合委员会癌症分期系统将粗甲状腺外延伸 (ETE) 分类为T3b.
- 外科医生的术内评估是主观的,可能会影响准确的T3b分期.
- 外科手术内ETE总评估的诊断准确性及其对复发结果的影响需要评估.
研究的目的:
- 在甲状腺癌中评估手术内粗体ETE评估的准确性.
- 为了确定T3b分期的错误分类是否会影响患者复发的结果.
- 为了确定不准确的手术内ETE评估的预测因素.
主要方法:
- 在2017-2022年间对4987名甲状腺切除术患者的分析.
- 根据手术内发现和最终病理学之间的一致性,分类为组:确认ETE,高估和低估.
- 临床特征,复发率和不准确评估的预测因素的比较.
主要成果:
- 在179名怀疑严重ETE的患者中,21.2%没有肌肉入侵病理.
- 在确诊的外来瘤 (6.4%),高估 (2.6%) 和低估 (3.0%) 组中,复发率没有显著差异.
- 年龄,瘤位置和淋巴侵入是不准确的手术内评估的独立预测因素.
结论:
- 在手术内进行的ETE总评估具有显著的不准确率.
- 虽然即时复发率相似,但准确的T3b分期可能会影响无复发生存率.
- 需要进一步的长期随访,以确认精确的手术内T3b鉴定的预后意义.
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