一个临床工作流程,用于评估在生物指导辐射治疗后,对有风险的器官的剂量
Thomas I Banks1, Chenyang Shen1, Andrew R Godley1
1Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cancers
|December 30, 2025
概括
这项研究引入了一种新的工作流程,用于在生物指导放射治疗 (BgRT) 治疗后评估风险器官 (OAR) 剂量. 该方法有助于监测剂量的一致性,并检测患者安全的重大变化.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 放射治疗技术 放射治疗技术
背景情况:
- 在生物指导放射治疗 (BgRT) 中,精确的剂量监测对于患者的安全至关重要.
- 在治疗后评估危险器官 (OAR) 的剂量对于评估分娩稳定性和确定临床问题至关重要.
研究的目的:
- 开发和实施一个系统的工作流程,以审查BgRT后的OAR剂量.
- 为了监测剂量输送的稳定性,并检测接受BgRT的患者临床上显著的变化.
主要方法:
- 实施了一种工作流程,该流程结合了RefleXion系统提供的剂量信息的定性审查和使用内部软件的定量评估.
- 开发了一个框架,从输送剂量分布计算定制的OAR剂量-体积指标,并可视化趋势.
- 该工作流被追溯应用于三个BgRT患者病例,以评估临床效用.
主要成果:
- 开发的工作流程有效地整合了RefleXion TPS功能和定制软件,用于BgRT后全面的OAR剂量评估.
- 一个电子表格工具有效地绘制了正常化的OAR剂量-体积指标,突出显著的剂量变化或耐受性违规.
- 工作流提供累积的递送剂量记录,有助于治疗监测和评估.
结论:
- 建立了BgRT后剂量评估工作流程,以定制OAR剂量-体积指标计算和图形来增强RefleXion数据.
- 这种工作流现在在临床实践中经常用于所有BGRT治疗.
- 未来的改进可能包括自动化,针对解剖变化的适应剂量计算,PET计量集成和目标剂量分析.
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