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在血管化中对编程细胞死亡的机制和翻译视角的全面审查

Yiyang Cao¹, Yulong Cao¹, Jiaheng Liu¹

¹The Queen Mary School, Jiangxi Medical College, Nanchang University, 999 Xuefu Road, Nanchang 330031, China.

|December 30, 2025

概括

编程细胞死亡 (PCD) 途径在血管化 (VC) 中至关重要. 针对像cuproptosis这样的新型PCD机制,为VC和动脉样硬化提供了潜在的治疗策略.

科学领域:

心血管生物学心血管生物学
细胞死亡机制细胞死亡机制
血管化的致病性.

背景情况:

编程细胞死亡 (PCD) 是一种受调节的细胞死亡 (RCD) 亚型,对平衡至关重要,并与各种疾病有关.
血管化 (VC) 涉及病态的沉积,导致血管功能受损和心血管事件风险增加.
目前尚不完全了解VC的分子基础,缺乏有效的治疗方法.

研究的目的:

审查各种PCD机制在VC病变发生中的作用.
探索cuproptosis作为动脉样硬化和VC的潜在治疗标.
综合有关VC中PCD通路及其治疗潜力的当前知识.

主要方法:

在VC中建立和新兴的PCD机制的系统审查.
分析与VC相关的信号网络.
讨论cuproptosis作为一个新的PCD模式.

主要成果:

PCD途径,包括亡,亡,自,铁亡,亡和热亡,有助于VC.
cuproptosis被确定为一种新的PCD机制,有可能成为动脉样硬化治疗标.
不同的PCD途径集体影响VC病变发生.

结论:

了解PCD在VC中的多方面的作用对于开发新疗法至关重要.
针对PCD,特别是像cuproptosis这样的新途径,对管理VC和相关心血管疾病充满希望.
对PCD机制的进一步研究可以阐明VC病因学,并指导治疗干预.

关键词:

分子信号传导转导的分子信号.被编程的细胞死亡.翻译目标的翻译目标.血管化血管化

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