探索Astragalus membranaceus在中枢神经系统疾病中的神经保护潜力
Jiajia Sang1, Jialin Gao1, Hui Zuo1
1Nanjing University of Chinese Medicine, Nanjing 210023, China.
Biomolecules
|December 30, 2025
概括
阿斯特拉加勒斯膜通过减少神经炎症和氧化应激,对治疗中枢神经系统 (中枢神经系统) 疾病有前途. 这种传统医学也正在发展成为用于预防和治疗中枢神经系统疾病的健康食品.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- (Astragalus membranaceus) 是一种传统的中医药,其在治疗中枢神经系统 (CNS) 疾病方面的潜力越来越得到认可.
- 它的治疗应用正在越来越多地被用于各种神经疾病.
研究的目的:
- 系统地审查A. membranaceus及其生物活性化合物对中枢神经系统疾病的作用机制.
- 探索治疗潜力,并引入来自A. membranaceus. 的相关健康食品产品.
主要方法:
- 从2015年1月到2025年7月,在PubMed和Web of Science进行了全面的文献搜索.
- 分析的重点是研究A. membranaceus.的神经保护作用和机制的研究.
主要成果:
- A. membranaceus及其化合物,特别是Astragalus IV (AS-IV) 和Astragalus polysaccharides (APS),表现出多方面的神经保护作用.
- 这些效应包括缓解神经炎症,氧化应激,亡,铁亡,调节自,并保护血脑屏障.
- 治疗潜力与调节NF-κB,Nrf2和PI3K/Akt等关键信号通路有关.
结论:
- 甲状腺菌是中枢神经系统疾病的有前途的多向药理学药剂,在健康食品配方中具有潜在的应用.
- 需要进一步进行高质量的临床研究,以验证其在人类中的有效性和安全性.
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