与年龄相关的人类适应极端气候因素和环境条件
Anna E Kallio1, Ekaterina A Davydova1, Tatiana A Mishchenko1
1Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia.
Biology
|December 30, 2025
概括
气候和城市化等环境影响加快了老龄化. 极端寒冷的气候和城市生活加快了生物衰老,影响了诸如血液白蛋白和红细胞RDW-CV等生物标志物.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 暴露组,包括终身环境暴露,显著影响健康和衰老.
- 将城市化和气候等环境因素与生理适应和寿命联系在一起的机制尚不清楚.
研究的目的:
- 为了确定由环境暴露影响的与衰老相关的生物标志物.
- 研究气候和城市化对生物衰老的影响.
主要方法:
- 在445名个体中对血液学和生物化学参数进行比较分析.
- 利用了莱文的PhenoAge模型和机器学习算法.
- 比较来自极度寒冷和较温和的城市气候的居民.
主要成果:
- 极端的气候条件与加速衰老和降低血液中白蛋白水平有关.
- 年龄加速与红细胞RDW-CV在不同气候区域之间呈现出正相关性.
- 在温带地区的小城镇中观察到较慢的衰老加速,这表明城市化是衰老的驱动因素.
结论:
- 环境暴露,特别是极端气候和城市化,显著影响生物衰老.
- 特定的生物标志物,如血液白蛋白和RDW-CV,与暴露基驱动的衰老加速有关.
- 这些发现可以为促进健康衰老的策略提供信息,以适应环境环境.
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