西利玛林植物晶体改善皮肤药物输送
Tehseen Sehra1,2, Muzn Alkhaldi1, Cornelia M Keck1
1Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.
Bioengineering (Basel, Switzerland)
|December 30, 2025
概括
植物晶体 (PCs) 增强了皮肤水分和皮肤透的脂性和不溶性活性成分 (API). 这些植物衍生子微粒对水友性API的有效性有限,细胞外囊泡形成有助于封装.
科学领域:
- 通过皮肤递送药物.
- 化品和药品中的纳米技术
- 植物衍生材料科学 植物衍生材料科学
背景情况:
- 植物晶体 (PlantCrystals,简称PCs) 是通过削或均质化生产的亚微米植物衍生颗粒.
- 以前的研究表明,PCs可以通过细胞外囊 (EV) 形成来改善脂友性活性成分 (API) 的皮肤传递.
- 该研究调查了PC适用于增强各种API类型的皮肤透的适用性.
研究的目的:
- 评估PlantCrystals对增强水友性,脂友性和难溶性API的皮肤透的作用.
- 为了比较PC配方的疗效与简单的溶液,经典的EV和后制备API的添加.
- 评估PC配方的皮肤保湿特性.
主要方法:
- 乳的种子被磨碎以产生西利玛林-PCs.
- 水友性,脂友性和难溶性API替代物被装入PC中.
- 皮肤透和皮肤水分被评估,使用ex vivo猪耳模型.
- 个人电脑的特点是尺寸,尺寸分布和泽塔潜力.
主要成果:
- 加工产生了微米以下的PC (约. 300 nm);装载的PC略大一些.
- PCs显著增强了皮肤透,特别是对脂性API (+90%).
- 在PC生产过程中形成EV有助于API封装,对脂性化合物最有效.
- 所有配方都提高了皮肤水分的30-40%.
结论:
- 乳种子是PC生产的合适来源.
- PCs有效地增强皮肤水分和皮肤透的脂性和不溶性API.
- 电脑表现出对水友性API的皮肤透的有限增强.
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