生物风险S (生物风险-口腔学):用于早期系统检测口腔学功能障碍的预测算法
Loredana Liliana Hurjui1, Liliana Sachelarie2, Carmen Stadoleanu2
1Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Str., 700115 Iasi, Romania.
Bioengineering (Basel, Switzerland)
|December 30, 2025
概括
生物风险-S算法使用常规实验室测试预测口腔性功能障碍,在症状出现之前识别亚临床炎症和代谢变化. 这种低成本的工具有助于对口腔和全身健康的早期干预.
科学领域:
- 口腔健康中的生物标志物和预测建模.
- 系统口腔健康的相互联系.
- 预防性医疗保健策略.预防性医疗保健策略.
背景情况:
- 牙神经系统功能障碍可能会在临床症状之前出现.
- 微妙的生物变化,如炎症,可能表明早期功能障碍.
- 生物风险S算法是为了检测亚临床系统性改变而开发的.
研究的目的:
- 引入和验证BioRisk-S算法,用于早期检测口腔性功能障碍.
- 评估系统生物标志物与早期功能变化之间的相关性.
- 为了评估BioRisk-S算法的预测准确度.
主要方法:
- 260名健康成年人在基线和6个月后被评估.
- 常规实验室测试测量了hs-CRP,NLR和维生素D.
- 生物风险S算法集成生物标志物来评估系统失衡.
主要成果:
- 较高的BioRisk-S得分与较高的hs-CRP,NLR和较低的维生素D相关.
- 具有高生物风险S分数的个体显示出功能障碍的早期迹象增加.
- 生物风险S算法显示出良好的预测准确性 (AUC=0.84).
结论:
- 生物风险S是一种可行的,低成本的工具,用于早期系统性查口腔位失衡.
- 在明显症状出现之前,它可以识别有风险的个体.
- 支持预防性和个性化的口腔和全身健康管理.
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