相关实验视频

Updated: Jan 7, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

使用基于患者的计算流体动力学来评估腹腔大动脉动脉瘤

Natthaporn Kaewchoothong¹, Sorracha Rookkapan², Chayut Nuntadusit¹

¹Department of Mechanical and Mechatronics Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai 90112, Songkhla, Thailand.

Bioengineering (Basel, Switzerland)

|December 30, 2025

概括

计算流体动力学揭示了腹腔大动脉动脉瘤 (AAA) 的动增加和特定的剪切应力模式. 这些血液动力学变化,特别是低时间平均壁剪应力和高振荡剪指数,可能表明破裂风险.

科学领域:

心血管科学心血管科学
生物医学工程生物医学工程
医疗成像医学成像

背景情况:

腹腔大动脉瘤 (AAA) 是一种危及生命的疾病,与破裂风险有关.
了解AAA内部的血液动力学变化对于风险评估至关重要.

研究的目的:

研究不同大小的患者特异性腹腔大动脉动脉瘤 (AAA) 的血液流动行为和血液动力学变化.
利用计算流体动力学 (CFD) 来分析流,墙面剪切应力和AAA中的振荡剪切指数.

主要方法:

从计算机断层扫描 (CT) 图像构建患者特定的AAA模型.
在AAA模型中应用计算流体动力学 (CFD) 来模拟血液流动.
包括一个健康的受试者和七名患有AAA (>3厘米直径) 的患者.

主要成果:

大动脉动脉瘤在透析阶段表现出显著的动荡,随着动脉瘤大小的增加而增加.
时间平均壁切应力 (TAWSS) 在心期间达到峰值,在心时降低.
在中间和远端动脉瘤囊中观察到较高的振荡剪切指数 (OSI),与较低的TAWSS相关.

结论:

CFD分析为AAA内部的血液流动动力学提供了宝贵的见解.
在AAA地区的低TAWSS和高OSI是增加墙壁破裂风险的潜在指标.
血液动力学参数分析有助于理解AAA病理生理学和破裂潜力.

关键词:

腹部大动脉动脉瘤腹部大动脉动脉瘤计算流体动力学流体动力学血动力学变化血动力学变化个性化模型个性化模型破裂的风险破裂的风险

更多相关视频

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

相关概念视频

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...