瓜叶提取物作为半固体药品中可持续的防腐剂替代品:有效性和稳定性评估
Hamada Imtara1, Mohammad Atiya2, Michel Hanania3
1Department of Biology and Biochemistry, Faculty of Medicine, Arab American University, Ramallah P600, Palestine.
Antibiotics (Basel, Switzerland)
|December 30, 2025
概括
果叶提取物显示为半固体药品中的天然防腐剂,有效抑制大多数配方中的细菌. 然而,它的抗真菌活性是有限的,需要进一步的配方改进,以保护广泛的光谱.
科学领域:
- 制药科学 制药科学
- 自然产品化学 自然产品化学
- 微生物学 微生物学
背景情况:
- 由于合成防腐剂的风险,药品中对天然防腐剂的需求日益增加.
- 瓜 (瓜) 叶提取物具有抗菌性质,使其成为一种可持续的保存选择.
- 评估瓜叶提取物作为各种制药基中的天然防腐剂.
研究的目的:
- 为了评估10% (w/w) Psidium瓜叶提取物作为天然防腐剂的有效性.
- 评估其对关键细菌和真菌物种的抗菌活性.
- 为了确定含有提取物的配方的化学,物理和微生物稳定性.
主要方法:
- 对 Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Aspergillus brasiliensis 和 Candida albicans 的抗菌活性进行测试.
- 按照USP/BP的指导方针进行加速稳定性研究 (40±2°C/75%±5%RH3个月).
- 高性能液态染色学 (HPLC) 分析以评估活性成分的稳定性.
主要成果:
- 克洛特里马奶油,甲酸奶油,珍塔米辛奶油和印美胺凝完全抑制了测试中的细菌物种.
- 观察到有限的抗真菌活性.
- 保存有效性标准仅适用于布洛芬凝和克洛特里马奶油.
- 尽管有颜色变化,但活性成分 (例如,布洛芬,克洛特里马) 的分解最小.
- 果叶提取物对抗真菌的有效性低于合成防腐剂 (甲基/甲) 的有效性.
结论:
- 松瓜叶提取物在特定的半固体制药配方中显示出作为天然防腐剂的潜力,提供抗菌保护和稳定性.
- 提取物显著的抗菌活性是值得注意的.
- 较弱的抗真菌活性需要优化配方,以提高保存效果.
更多相关视频
05:45Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
4.2K
11:27A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
2.4K
相关概念视频
01:22Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
162
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
162
01:16Drug Product Stability
208
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
208
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
180
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
180
01:17In Vitro Drug Dissolution: Alternative Methods
178
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
178
01:19Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence
152
Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
152
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
376
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
376